2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W001094
    2-Bromo-4-fluoroanisole 452-08-4 99.69%
    2-Bromo-4-fluoroanisole is an important intermediate in organic synthesis. 2-Bromo-4-fluoroanisole can be used in the research of diabetic complications (including blindness).
    2-Bromo-4-fluoroanisole
  • HY-W007828
    Methyl 3-phenylpropanoate 103-25-3 ≥98.0%
    Methyl 3-phenylpropanoate is a phenylpropionate compound. Methyl 3-phenylpropanoate derivatives interfere with insect feeding behavior. Methyl 3-phenylpropanoate can be used to study insect feeding behavior.
    Methyl 3-phenylpropanoate
  • HY-W009247
    N-Desmethylolanzapine 161696-76-0 ≥98.0%
    N-Desmethylolanzapine is an antipsychotic drug. The formation of N-Desmethylolanzapine correlates with the level and activity of human liver flavin-containing monooxygenase (FMO3). N-Desmethylolanzapine can be used in the study of antipsychotic drugs .
    N-Desmethylolanzapine
  • HY-W009706
    Alclofenac 22131-79-9 99.44%
    Alclofenac (Allopydin) is an orally active prostaglandin synthase inhibitor with anti-inflammatory, analgesic and antipyretic activities. Alclofenac irreversibly inhibits platelet aggregation. Alclofenac can be used in research related to rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, low back pain and sciatica.
    Alclofenac
  • HY-W013788
    2-Palmitoylglycerol 23470-00-0 99.0%
    2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119.
    2-Palmitoylglycerol
  • HY-W014700
    Glycyl-L-glutamic acid 7412-78-4
    Glycyl-L-glutamic acid is a neurotrophic factor (NF) in vivo, and exerts function of maintenance of AChE content and activity. Glycyl-L-glutamic acid doesn’t act directly on AChE synthesis, and may prevent preganglionic neuronal degeneration.
    Glycyl-L-glutamic acid
  • HY-W015815
    6-Methylnicotinamide 6960-22-1
    6-Methylnicotinamide is a nicotinamide derivative. 6-methylnicotinamide is also an endogenous metabolite and its sudden increase in the acute stages of intracerebral hemorrhage (ICH) exacerbates neurological damages in rat model. 6-Methylnicotinamide can significantly enhance the coordination effect between acylamino and undercoordinated defective Pb2+ cations. 6-Methylnicotinamide results in enhanced efficiency of perovskite solar cells to 24.33% with excellent environmental storage, heat, and light stabilities.
    6-Methylnicotinamide
  • HY-W033027
    BGT1-IN-1 406947-32-8
    BGT1-IN-1 (compound 9) is a potent BGT1 inhibitor with IC50 value of 13.9, 58.3 µM for hBGT1, GAT3, respectively. BGT1-IN-1 shows no cytotoxic. BGT1-IN-1 shows neuroprotective activity.
    BGT1-IN-1
  • HY-W068771
    (E)-3-(4-Methoxyphenyl)acrylic acid 943-89-5 ≥98.0%
    (E)-3-(4-Methoxyphenyl)acrylic acid (compound 3) is isolated from Arachis hypogaea, Scrophularia buergeriana Miquel, Aquilegia vulgaris, Anigozanthos preissii and so on. (E)-3-(4-Methoxyphenyl)acrylic acid shows significant hepatoprotective activity, anti-amnesic, cognition-enhancing activity, antihyperglycemic, and neuroprotective activities.
    (E)-3-(4-Methoxyphenyl)acrylic acid
  • HY-W278867
    trans-3,5-Dimethoxystilbene 21956-56-9 98.45%
    trans-3,5-Dimethoxystilbene (trans-Pinosylvin dimethyl ether) is a natural stilbenoid metabolite. trans-3,5-Dimethoxystilbene acts as an acetylcholinesterase inhibitor with a IC50 of 9 μM against Electrophorus electricus acetylcholinesterase. trans-3,5-Dimethoxystilbene binds to acetylcholinesterase and blocks acetylcholine hydrolysis, thereby increasing acetylcholine levels in the cholinergic synaptic cleft. trans-3,5-Dimethoxystilbene can be used in the research of neurodegenerative diseases such as Alzheimer's disease.
    trans-3,5-Dimethoxystilbene
  • HY-W453397
    Aberrant tau ligand 1 1892461-96-9 ≥98.0%
    Aberrant tau ligand 1 is a tau protein ligand. Aberrant tau ligand 1 engages tau and CRBN to trigger proteasomal degradation. Aberrant tau ligand 1 can be used for synthesis PROTACs, such as QC-01–175 (HY-134850).
    Aberrant tau ligand 1
  • HY-W654003
    D-α-Hydroxyglutaric acid-d5 disodium 98.14%
    D-α-Hydroxyglutaric acid-d5 disodium (Disodium (R)-2-hydroxyglutarate-d5) is the deuterium labeled D-α-Hydroxyglutaric acid disodium (HY-100542). D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling.
    D-α-Hydroxyglutaric acid-d5 disodium
  • HY-W775306
    Cannabidivarinic acid 31932-13-5 99.67%
    Cannabidivarinic acid (CBDVA), the carboxylic acid precursor of Cannabidivarin(CBDV), is a non-psychoactive cannabinoid found in Cannabis with anti-inflammatory properties.
    Cannabidivarinic acid
  • HY-W841438
    Lithium orotate 5266-20-6 98%
    Lithium orotate is an orally active lithium supplement with reduced binding that can bypass amyloid sequestration in AD mice models. Lithium orotate can prevent Aβ plaque deposition and phospho-tau accumulation and reverse AD pathology, neuroinflammatory changes and memory loss in AD mice models and ageing wild-type mice. Lithium orotate can be used for the research of alcoholism and Alzheimer’s disease.
    Lithium orotate
  • HY-Y0921S2
    (±)-1,2-Propanediol-d6 52910-80-2 99.97%
    (±)-1,2-Propanediol-d6 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents.
    (±)-1,2-Propanediol-d6
  • HY-121883S4
    Lignoceric acid-d4-2 1219794-61-2 98.7%
    Lignoceric acid-d4-2 is the deuterium labeled Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research.
    Lignoceric acid-d4-2
  • HY-W008719S
    MPP+-d3iodide 207556-07-8 99.21%
    MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT).
    MPP+-d3iodide
  • HY-W011051S1
    2-Arachidonoylglycerol-d5 2522598-88-3 ≥99.0%
    2-Arachidonoylglycerol-d5 is the deuterium labeled 2-Arachidonoylglycerol. 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand in the central nervous system.
    2-Arachidonoylglycerol-d5
  • HY-13056
    SMND-309 1065559-56-9
    SMND-309 is a metabolite of salvianolic acid B, and exhibits neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats.
    SMND-309
  • HY-14794
    Dextromilnacipran 96847-55-1 99.90%
    Dextromilnacipran ((1R,2S)-Milnacipran; F2696) is an orally active Serotonin (HY-B1473A)/Noradrenaline (HY-13715) transporter inhibitor. Dextromilnacipran inhibits Serotonin and Noradrenaline reuptake. Dextromilnacipran can be used for the research of depression, fibromyalgia.
    Dextromilnacipran
Cat. No. Product Name / Synonyms Application Reactivity